Party over the Weekend?

So, the more you drink, the more you impair the CNS. The more you impair the CNS, the more dependent you become on peripheral mechanisms. A good reason to keep your vestibular system (alcohol changes the specific gravity of the endolymph), your visual system (long term use affects the option nerve directly and can cause involuntary saccades) and proprioceptive systems including the cutaneous mechanoreceptors (because you are relying on them more) intact. Watch what and how much you drink...

"Standing postural stability relies on input from visual, vestibular, proprioceptive and mechanoreceptive sensors. When the information from any of these sensors is unavailable or disrupted, the central nervous system maintains postural stability by relying more on the contribution from the reliable sensors, termed sensory re-weighting. Alcohol intoxication is known to affect the integrity of the vestibular and visual systems. The aim was to assess how mechanoreceptive sensory information contributed to postural stability at 0.00% (i.e. sober), 0.06% and 0.10% blood alcohol concentration (BAC) in 25 healthy subjects (mean age 25.1 years). The subjects were assessed with eyes closed and eyes open under quiet standing and while standing was perturbed by repeated, random-length, vibratory stimulation of the calf muscles. Plantar cutaneous mechanoreceptive sensation was assessed for both receptor types: slowly adapting (tactile sensitivity) and rapidly adapting (vibration perception). The correlation between recorded torque variance and the sensation from both mechanoreceptor types was calculated. The recorded stability during alcohol intoxication was significantly influenced by both the tactile sensation and vibration perception of the subjects. Moreover, the study revealed a fluctuating association between the subjects' vibration perception and torque variance during balance perturbations, which was significantly influenced by the level of alcohol intoxication, vision and adaptation. Hence, one's ability to handle balance perturbations under the influence of alcohol is strongly dependent on accurate mechanoreceptive sensation and efficient sensory re-weighting. 

Modig F, Patel M, Magnusson M, Fransson PA.Study II: mechanoreceptive sensation is of increased importance for human postural control under alcohol intoxication. Gait Posture. 2012 Mar;35(3):419-27. doi: 10.1016/j.gaitpost.2011.11.001. Epub 2011 Dec 27.
weighting.